Browns right tackle John St. Clair will miss his second straight game with an ankle injury, inactive for Sunday's home game against Jacksonville.
Also inactive for the Browns are defensive end Kenyon Coleman (ankle, elbow), receiver Brian Robiskie (ankle), linebacker Titus Brown (hamstring), defensive backs Coye Francies and Gerard Lawson and tight end Greg Estandia.
Floyd Womack will start for St. Clair, with Rex Hadnot taking Womack's spot at right guard. Corey Williams will replace Coleman at left end.
The Jaguars will be without three starters -- receiver Torry Holt (hand), tight end Marcedes Lewis (cheek, head) and cornerback Rashean Mathis (groin). Mike Thomas will start in place of Holt, Earnest Wilford for Lewis and Tyson Brackenridge for Mathis.
Also sitting out for Jacksonville are defensive back Kennard Cox, center Cecil Newton, offensive tackle Tra Thomas, offensive lineman Paul McQuistan and defensive end Julius Williams.