Browns tight end Kellen Winslow (undisclosed illness), right tackle Kevin Shaffer (concussion) and defensive end Shaun Smith (hand surgery) were among the inactives for Monday night's game against the Giants.
They will be replaced in the lineup by Steve Heiden, Ryan Tucker and Louis Leonard, respectively.
Also active for the first time this season is No. 2 receiver Donte' Stallworth, who strained his quad before the season opener against Dallas.
Other Browns inactives are strong safety Sean Jones, defensive back Hamza Abdullah, offensive lineman Scott Young, tight end Martin Rucker and third quarterback Ken Dorsey.
Among the Giants inactives are kicker Lawrence Tynes, safety Sammy Knight, cornerback Sam Madison and receiver Sinorice Moss.