The Indians dropped their fourth straight game and third straight against the Red Sox 6-2 on Thursday night.
The Tribe stayed within one run until the seventh inning, when some sloppy defense played a part in a three-run inning for the Red Sox.
Indians starting pitcher Zach McAllister lasted five innings, gave up three earned runs and struck out seven. Nack Hagadone came on in relief and gave up a run in one inning and Bryan Shaw allowed two more runs in two innings.
The offense only mustered four hits against Jon Lester in his seven innings and had to manufacture both runs. Mark Reynolds scored on Mike Aviles' ground ball in the second inning following a double and a sacrifice fly, and Drew Stubbs knocked Aviles in on another ground ball in the fifth.
In the eighth, Drew Stubbs walked and Michael Brantley singled to left. With two outs, Carlos Santana doubled to right field to score Stubbs and bring the trying run to the plate in Nick Swisher, who struck out to end the threat.
Santana went 2-4 with an RBI, which included a hard line-drive out that he just happened to hit right at left fielder Daniel Nava.
The Indians now travel to Houston for a three-game weekend set with the Astros.