Here's a recent story from Science Daily about research into a how a gene mutation may lead to autistic disorders. To study this mutation, scientists had to genetically engineer a mouse to experiment on.
For a fascinating and highly readable account of how scientists make mouses, see Pulitzer-prize winning science writer Jon Franklin's story "To make a mouse," originally published in the Raleigh News and Observer in 1999. (Full disclosure, Jon Franklin was my journalism professor and mentor at the University of Oregon.)
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