Michael J. Fox has weighed into a political race in this spot. It's very powerful and makes its point both in what Fox says and in how he looks.
It reminds me of some other forceful ads from bygone days, especially a couple of anti-smoking spots. One featured William Talman, who played Hamilton Burger on ''Perry Mason.'' You can find it here, and it still packs a punch because Talman is so ravaged by his illness. Yul Brynner also arranged for one, which is on view here.