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WASHINGTON: For those of us with a certain political bent and background, this is the most depressing moment of all. The best of the GOP — Marco Rubio and Paul Ryan, the intellectually serious reformicons who have called attention to issues of poverty and the need for Republican outreach — are bending their knee to the worst nominee in their party’s history. Ryan drags himself slowly. Rubio eventually went with a quick Band-Aid pull. But the largest political choice each man has made this year will be one of the worst mistakes of their careers.