Interstate 76 westbound was closed Thursday morning because of a fatal two-vehicle crash in Lake Milton in Mahoning County.
A Chevrolet Trailblazer heading east traveled across the median at 7:49 a.m. and collided head-on with a tractor-trailer, the Ohio Highway Patrol said.
Two people in the sport utility vehicle were killed and two others were taken to St. Elizabeth Health Center in Youngstown with critical injuries.
The Youngstown Vindicator reported that the two people who died are children ages 9 and 12.
The condition of the truck driver was unknown.
The Ohio Department of Transportation reported that the highway reopened around 11:30 a.m.
Further details were unavailable.