All CATEGORIES
☰ Menu

Studies test how early in life to peek inside DNA

By Lauran Neergaard
Associated Press

WASHINGTON: Little Amelia Sloan became a pioneer shortly after her birth.

The healthy baby is part of a large research project outside the nation’s capital that is decoding the DNA of hundreds of infants. New parents in a few other cities soon can start signing up for smaller studies to explore whether what’s called genome sequencing — fully mapping someone’s genes to look for health risks — should become a part of newborn care.

It’s full of ethical challenges.

Should parents be told only about childhood threats? Or would they also want to learn if their babies carried a key gene for, say, breast cancer after they’re grown? Could knowing about future risks alter how a family treats an otherwise healthy youngster? And how accurate is this technology — could it raise too many false alarms?

This is the newest frontier in the genetic revolution: how early to peek into someone’s DNA, and how to make use of this health forecast without causing needless worry.

“This was something that was looming over the horizon,” said Dr. Alan Guttmacher, a pediatrician and geneticist who heads the National Institutes of Health’s child health division. Last month, NIH announced a $25 million, five-year pilot project in four cities — Boston, San Francisco, Chapel Hill, N.C., and Kansas City, Mo. — to start answering some of the questions before the technology is widely offered for babies.

Today, the 4 million U.S. babies born annually have a heel pricked in the hospital, providing a spot of blood to be tested for signs of at least 30 rare diseases. This newborn screening catches several thousand affected babies each year in time for early treatment to prevent death, brain damage or other disabilities. It’s considered one of the nation’s most successful public health programs.

A complete genetic blueprint would go well beyond what that newborn blood spot currently tells doctors and parents — allowing a search for potentially hundreds of other conditions, some that arise in childhood and some later, some preventable and some not.

“If I truly believed that knowing one’s genome was going to be transformative to medicine over the next decade or more, then wouldn’t I want to start generating that information around the time of birth?” asked Dr. John Niederhuber, former director of the National Cancer Institute who now oversees one of the largest baby-sequencing research projects to date.

At Niederhuber’s Inova Translational Medicine Institute in Falls Church, Va., researchers are mapping the genomes of newborns, along with their parents and other relatives for comparison. The long-term goal of the privately funded study is to uncover genetic patterns that predict complex health problems, from prematurity to developmental disorders.

Parents will only learn of gene mutations that cause treatable or preventable conditions — so-called medically actionable findings.



MORE IN NEWS

 
  • Main Blog Promo
  • Cavs Blog Promo
  • Browns Blog Promo
  • Indians Blog Promo
  • Beer Blog Promo
  • Fracking Blog Promo
  • High School Blog Promo
  • Zips Blog Promo
  • Akron Dish Food Blog
Prev Next