1. The Browns’ eight sacks are tied for second-most in the NFL, but getting to Buffalo Bills quarterback Ryan Fitzpatrick won’t be so easy. The Bills are the only team in the league that hasn’t allowed a sack yet. They have an experienced offensive line and Fitzpatrick gets rid of the ball quickly.
2. When Fitzpatrick is good, he looks like Jim Kelly. When he’s bad, he’s Spergon Wynn. The Browns haven’t stopped the run in 13 years, meaning their best chance at victory is to force Fitzpatrick into mistakes. He threw three interceptions in the Bills’ opener against the New York Jets and they lost by 20 points.
3. Rookie right tackle Mitchell Schwartz might have the most important matchup as he tries to stave off Mario Williams, the Bills’ $100 million sack specialist. Williams, who signed with the Bills as a free agent during the summer, has 53 sacks since entering the league with the Houston Texans in 2006. Schwartz played pretty well last week against the Bengals, but Williams’ pass-rushing skills are elite. This will be one of the best defensive lines the Browns face all season and Williams is a huge reason why.
4. The secondary must do a better job against Stevie Johnson than it did last week defending A.J. Green, who had seven catches and a touchdown. Johnson averages 18.5 yards per catch to rank third in the league and has been ranked among the game’s top receivers for the last few years.
5. Brandon Weeden must hold on to the ball amid what could be a furious pass rush from the Bills. Weeden didn’t fumble at all last week, a vast improvement over the preseason and the opener against the Philadelphia Eagles, when he had five fumbles in nine combined quarters.