1. As expected, Brian Hoyer has been named the Browns’ starting quarterback for the third consecutive game. Brandon Weeden (sprained right thumb) has been medically cleared to play, but coach Rob Chudzinski is sticking with Hoyer. Chudzinski has yet to name the No. 2 quarterback, Weeden or Jason Campbell. On the other side will be a quarterback Chudzinski could have drafted, Buffalo Bills rookie E.J. Manuel.
2. Browns running back Willis McGahee had an expanded role in his second game this season, running for 46 yards on 15 carries against the Cincinnati Bengals. He is determined to improve each game. He’ll have to do it this time against the Bills, the team that drafted him No. 23 overall in 2003.
3. The Browns will need to slow down Bills defensive end Mario Williams, who’s third in the league with 5½ sacks. He tormented the Carolina Panthers in Week 2 with 4½ sacks. The last time Williams came to Cleveland, he had 1½ sacks. He’s been slightly banged up with an ankle injury.
4. If the Bills do anything well, it’s running the ball. The Bills are ranked No. 2 in the league in rushing yards per game (152), and both C.J. Spiller and Fred Jackson pose threats on the ground, although both are banged up. Still, Browns defensive coordinator Ray Horton said he expects Spiller (ankle) and Jackson (knee) to play.
5. Browns rookie outside linebacker Barkevious Mingo is expected to make his second consecutive start because Jabaal Sheard is expected to sit out with a sprained left knee. Mingo has a chance to become the first player to get at least one sack in each of his first four NFL games since Terrell Suggs did it in 2003 with the Baltimore Ravens.