As everyone must know by now, Fox’s animated series Family Guy lives to lampoon human nature and human frailties.

There’s something bracing as it blows its whistle on a society that seems to grow ever coarser and more mean-spirited, while individuals squawk at any hint of disrespect and wilt at every trigger word.

The show, with its deft blend of the ingenious and the rude-and-crude, provides a counteractive space where no low blow, regardless of how low, is inadmissible. And so it carries on, as porky patriarch Peter Griffin and his family and friends begin their 16th season on Sunday (9 p.m. Eastern) on Fox.

Show runners Rich Appel and Alec Sulkin recently shared some details of what lies ahead — including the series’ 300th episode, which won’t be just a milestone, Appel promises, “but one of our best.”

The season premiere, said Sulkin, “will be our shameless grab to win a [best show] Emmy” — an itch so far unscratched by the Television Academy.

As Peter embarks on his own For Your Consideration campaign, he will make Family Guy more like proven Emmy-winning shows, including not just comedy but also dramas and reality. Guest voices include Sofia Vergara, Ty Burrell, Julie Bowen, Louis C.K., Bill Maher, Christina Pickles and the late Adam West.

What else?

“We’ll have a special episode where [precocious toddler] Stewie is in therapy for the entire half-hour,” said Sulkin, “with the therapist played by Sir Ian McKellen.”

Another episode, titled Three Directors, will tell the same simple story — Peter losing his job, “but each version is told in the style of Quentin Tarantino, Wes Anderson and Michael Bay,” Appel said.

“We have an episode where Brian [the erudite, articulate family dog] and Stewie go back to Victorian England and play Sherlock Holmes and Dr. Watson,” said Sulkin.

The series, which premiered in 1999, was created by Seth MacFarlane, who handed over the reins as showrunner in 2010 to pursue other projects, including two Ted films and, currently, his new Fox sci-fi series The Orville.

But he continues to voice a number of Family Guy characters, “and while he’s recording if there are things that he doesn’t like, or does like, he will let us know,” Sulkin said.

One of MacFarlane’s signature elements in the show is its cutaway gags and comic asides. Peppered through each episode, those cutaways are where some of its sharpest comedy resides, and where the series takes its wildest flights of fancy. “It’s one of Seth’s brilliant strokes,” said Appel. “The cutaways predate YouTube and Hulu clips, and anticipated the shared content of my kids’ generation.”