MONTPELIER, Vt.

Senator will take on Clinton

Promising to fight what he deems “obscene levels” of income disparity and a campaign finance system that is a “real disgrace,” independent Vermont Sen. Bernie Sanders said Wednesday he will run for president as a Democrat. In an interview with the Associated Press, Sanders confirmed his plans to formally join the race Thursday. The self-described “democratic socialist” enters the race as a robust liberal alternative to Hillary Rodham Clinton, and he pledged to do more than simply raise progressive issues or nudge the former secretary of state to the left in a campaign in which she is heavily favored.

WASHINGTON

GOP unveils budget proposal

Republicans controlling Congress on Wednesday unveiled a budget plan for the upcoming year and beyond, setting up a confrontation with President Barack Obama over his signature health-care law and his vow to boost spending on domestic programs like transportation and education. House-Senate negotiators on the sweeping — but nonbinding — budget plan sealed agreement Wednesday. The 10-year balanced budget plan calls upon lawmakers to repeal Obama’s health-care law while enacting major curbs on safety net programs like Medicaid and food stamps. It would cut future-year budgets for domestic agencies.

CAPE CANAVERAL, Fla.

Space station supply ship lost

A Russian supply capsule that went into an uncontrollable spin after launch was declared a total loss Wednesday, but astronauts at the International Space Station said they will get by without the delivery of fresh food, water, clothes and equipment. NASA astronaut Scott Kelly and Russian Mikhail Kornienko, the space station’s one-year crew members, said flight controllers had given up trying to command the cargo carrier. NASA and the Russian Space Agency later confirmed the news. The capsule is expected to burn up harmlessly in the atmosphere, as is the case for all Progress carriers, once they have delivered their shipments and are filled with trash.

NEW YORK

Drug approved for double chins

The Food and Drug Administration said Wednesday it approved an injection designed to melt away double-chin fat. The agency approved a drug called Kybella for adults with moderate or severe fat below the chin, or submental fat. It’s the first approved drug for Kythera Biopharmaceuticals. The drug is a synthetic form of deoxycholic acid, a chemical the FDA said is naturally produced by the body and helps it absorb fats. It destroys fat cells by breaking down the cell membrane.

Compiled from wire reports