The Cavs will be without guard Dwyane Wade for Friday night's game against the Indiana Pacers at Quicken Loans Arena.

Wade, who also missed shootaround, is dealing with a personal issue. Coach Tyronn Lue said general manager Koby Altman told Wade to take as much time as he needs.

The leader of the Cavsí second unit, Wade had scored in double figures in four consecutive games. Heís averaging 11.1 points, 3.9 rebounds and 3.7 assists in 23.1 minutes of 37 games.

Lue told Jose Calderon to be ready for action. Derrick Rose, Kyle Korver, Jeff Green, Jae Crowder and Channing Frye will make up the second unit.

Rose is just four games into his return from a sprained left ankle complicated by a bone spur and still on a minutes restriction. Frye has not played in three of the past five games and was inactive in San Antonio Tuesday with an abdominal strain.