1. The Browns listed rookie defensive end Myles Garrett as questionable to face the Bengals, but he’s expected to sit out his fourth consecutive game with the right high-ankle sprain he suffered Sept. 6. The defense will need to find a way to pressure Bengals quarterback Andy Dalton without the No. 1 overall pick in this year’s draft. The Browns are tied for 21st in the NFL with just six sacks. They could be without another key player on the defensive line because tackle Danny Shelton is questionable with a calf injury. “Danny is a tough guy and loves to be out there,” Browns coach Hue Jackson said. “So if there is any way possible he can be, he will be.” Starting strongside linebacker Jamie Collins has been ruled out with a concussion.

2. How the Browns handle the national anthem will be a point of interest after owners Dee and Jimmy Haslam, cornerback Jason McCourty, linebacker Christian Kirksey and tight end Randall Telfer were among 20-25 owners and players who met with NFL Commissioner Roger Goodell on Tuesday at league headquarters in New York regarding protests. “We’re always going to try to bring this world together,” Browns cornerback Jamar Taylor said. “Sports bring the world together. So we’re just going to continue to focus on Cincinnati but, at the same time, when we do protest, or whatever we do, we’re just going to try to bring unity and God into the equation.”

3. The Browns and the Bengals are both looking for their first win. The Bengals hold a 48-39 edge in the series, which started in 1970. The Bengals have won five games in a row in the series, all by double figures. “It is a Battle of Ohio,” Jackson said. “Obviously, the Bengals have done a good job on their part. We need to do better, and we get it. To make it a rivalry, we have to start winning some of these games. It is just that simple. I think our guys understand that.”

4. Bengals linebacker Vontaze Burfict will make his 2017 regular-season debut after serving a three-game suspension for delivering an illegal hit on Kansas City Chiefs fullback Anthony Sherman in the preseason. He’s a habitual violator of the NFL’s player safety rules, and Jackson warned his players about Burfict in Wednesday’s team meeting. “Vontaze is always intense,” Browns right guard Kevin Zeitler said. “He is a very good player. He is definitely back, and I’m sure it will have a big impact for their defense.”

5. Notable connections: Jackson coached in Cincinnati from 2004-2006 and 2012-2015. The Bengals won two AFC Central Division titles and reached the playoffs in each of the past four seasons. ... Zeitler signed with the Browns in the offseason after playing for the Bengals from 2012-2016. He was originally selected by the Bengals in the first round (27th overall) of the 2012 NFL Draft and then started 71 of 72 games. ... Hall of fame coach Paul Brown was the Browns’ first head coach and general manager. He coached the Browns from 1946-1962, and led them to four AAFC championships (1946-1949) and three NFL titles (1950, 1954, 1955). Including the regular season and playoffs, he compiled a 115-49-5 record in the NFL with the Browns and a 52-4-3 mark in the AAFC. He later founded the Bengals and became their first head coach and general manager, posting a record of 55-59-1 from 1968-1975 with three playoff appearances.