1. The Browns need to limit Chargers six-time Pro Bowl quarterback Philip Rivers and the NFL’s fourth-ranked passing attack (263.9 yards per game). “He is right at the top [of the list of quarterbacks I’ve faced],” Browns cornerback Jason McCourty said. “If you turn that [Thanksgiving Day] game on against the Cowboys [when the Chargers won 28-6 in Dallas], how could he not be? What you enjoy about him is he’s a fiery competitor. You just see him out there, even as a quarterback, in guys’ faces yelling, passionate, and he can make every single throw.”

2. Keeping Chargers defensive ends Joey Bosa (10.5 sacks) and Melvin Ingram (8.5 sacks) from crushing rookie quarterback DeShone Kizer is paramount for the Browns linemen. “They are both outstanding edge rushers,” Chargers coach Anthony Lynn said of Bosa and Ingram. “They are still learning to push the pocket inside. Sometimes we put them inside just trying to create matchups, but I think they complement each other very well. They are just high motor guys. They are going to bring it every single play.”

3. The Browns must slow down Keenan Allen, who has had 12 catches for 159 yards and two touchdowns and 11 catches for 172 yards and one touchdown in the past two games. “Philip Rivers is one of those few, select quarterbacks in the league that will throw you open and allow you to run with the ball when you catch it,” Browns defensive coordinator Gregg Williams said. “Our big job is going to be able to not only have leverage and coverage ability on Keenan, but also be in those windows of opportunity that Philip Rivers creates by throwing him open. [Allen] has very good agility and very good speed once he catches the ball.”

4. Kizer has been inconsistent all season, but the Browns need him to end the trend by following a good outing against the Cincinnati Bengals with another efficient performance. Last week in Cincinnati, he avoided a turnover for just the second time this season after committing four turnovers in the previous game against the Jacksonville Jaguars. “He’s a tough kid, and he’s learning every week so I think that shows real maturity on him to be able to clear a bad game … and bounce back and have a better game,” Browns left tackle Spencer Drango said.

5. Can the Browns exploit the main weakness of the Chargers defense? The Chargers are last in the NFL in run defense (133.5 yards allowed per game). The Browns rushed for 169 yards on 31 carries (5.5 average) and a touchdown last week against the Bengals. Starting running back Isaiah Crowell had 16 carries for a season-high 95 yards (5.9 average) in Cincinnati. “We’ve been running the ball really well, I think it kinda speaks to just the plan that we have going into the week and just the execution that we’ve had upfront,” Drango said.