Ohio State suffered the biggest drop in the Associated Press Top 25 after two double-digit losses last week.

The Buckeyes (22-7, 13-3 Big Ten) lost on the road at Penn State and Michigan and fell from No. 8, the highest position they had held this season, to No. 16 and out of first place in the Big Ten.

Virginia strengthened its hold on No. 1 as it coasts to an Atlantic Coast Conference regular-season title, while Duke made a big jump after two impressive wins without its top freshman.

The Cavaliers earned 42-of-65 first-place votes in the poll released Monday. That’s 12 more than last week, when they reached No. 1 for the first time since the Ralph Sampson era.

The top four remained unchanged, with No. 2 Michigan State earning 19 first-place votes after rallying from 27 behind to beat Northwestern. Third-ranked Villanova got the other four first-place votes after winning at No. 4 Xavier. And Duke jumped seven spots to No. 5 after beating Virginia Tech and Clemson despite playing without Marvin Bagley, the ACC’s scoring and rebounding leader who is recovering from a knee sprain.

Virginia (24-2, 13-1 ACC) long ago took the drama out of the ACC race with a 12-0 start and hasn’t played since winning at Miami last Tuesday. The Cavaliers lead second-place Duke by three games in the loss column and own the head-to-head tiebreaker from their win at Cameron Indoor Stadium on Jan. 27, so they can clinch at least a share of the regular-season title and the No. 1 seed for the ACC Tournament in Brooklyn by beating Georgia Tech on Wednesday.

It was a tough week at the top of last week’s poll, with seven of the top 10 teams losing at least once, so there was a shuffle Monday.

Texas Tech and Gonzaga were tied for No. 6, with the Red Raiders inching up a spot and the Bulldogs moving up three. Kansas jumped five spots to No. 8 after beating West Virginia, followed by Purdue (which slid three spots) and North Carolina — which has won five straight and climbed four spots to No. 10.

Middle Tennessee checked in at No. 24, marking the first AP Top 25 poll appearance in program history.

Oklahoma and freshman Trae Young — the nation’s scoring and assists leader — went from unranked in the preseason all the way to No. 4 on Jan. 15. But the Sooners have collapsed with five straight losses and that sent them back to unranked status.

Two other teams that had reached the top 5 as of Christmas Day fell out of the poll again. Texas A&M, which peaked at No. 5, fell out from No. 21 after losses to Missouri and Arkansas. Arizona State, which peaked at No. 3, fell out from No. 25 after losing to Arizona.