Mad Magazine, the once-subversive humor publication that helped redefine American satire and influenced a half-century of comedians and comic artists, will soon disappear from the newsstand. And after October, it will cease being the fresh creative force that it was across seven decades.

"Age hits everybody: It hits magazines, it hits the movies, it hits technology," Mad cartoonist Sergio Aragones told the Washington Post on Thursday. "It's been a logical development."

Mad Magazine hit a peak of more than 2 million subscribers in the early '70s, when it memorably satirized shifting social mores and cultural attitudes. Emblematic of that era — when Mad flexed the most pop-culture muscle as a powerhouse of fresh irreverence — was a Watergate-era send-up of President Richard Nixon and Vice President Spiro Agnew in a "big con" spoof of the hit Oscar-winning movie "The Sting."

But commercial pressures had changed since the '90s. To try to survive in more recent years, as circulation dwindled precipitously, the magazine owned by Warner Bros.' DC division shifted to a quarterly publishing schedule and moved its offices from New York to the Los Angeles area. Now, the Mad brand will mostly endure by simply recirculating its classic vintage material, living on through the appeal of what it once was.

"We have influenced or entertained a great many people who are now grown and introduced it to their children," another renowned Mad cartoonist, Al Jaffee, told the Washington Post on Thursday. "It's mostly nostalgia now."

Mad will begin disappearing from newsstands, though it will remain available to subscribers and through comic shops. After this fall, the magazine will produce no new content, except for the end-of-year specials. All issues after that will be republished content culled from 67 years of publication, and Mad will continue to publish books and special collections, multiple sources told the Post. DC declined a request for comment.

"Of course, we all knew this was coming," veteran Mad artist Tom Richmond wrote on his blog Thursday. "Last week, DC laid off one art director and three of the four remaining editors. Not too many magazines can keep publishing without any staff."

"Mad had an incalculable influence on satire, comedy in general, and the humor of the entire planet," wrote Richmond, adding that it "regularly featured some of the greatest cartoonists who ever lived like Harvey Kurtzman, Jack Davis, Mort Drucker, Wally Wood, Will Elder, Al Jaffee, Sergio Aragones, Don Martin, Paul Coker ... too many to list, really."

"From Kurtzman to [Al] Feldstein to [Nick] Meglin to [John] Ficarra, each editor brought their own talent," Aragones said of the leadership that spanned most of the magazine's history since its founding in 1952, when mainstream outlets for subversive humor were far less common.

"What made it great was the writers and the artists — it was an incredible group — and the team was special. because of the trust between editors and the talent," added Aragones, 82, whose work has appeared in nearly every issue since 1962.