ANAHEIM, Calif. — Carlos Santana and Francisco Lindor homered, Carlos Carrasco won in relief and the Indians defeated the Los Angeles Angels 4-3 Wednesday night to cap a successful road trip.

The Indians went 5-1 against the Minnesota Twins and Angels and are a half-game behind the Oakland Athletics for the second American League wild-card spot. The Indians trail the AL Central-leading Twins by four games heading into a three-game series at home against the Twins this weekend.

Carrasco (5-7), making his fifth appearance since being treated for leukemia, pitched 1 2/3 scoreless innings with two walks and two strikeouts. The right-hander threw 30 pitches, the most during his comeback.

With All-Star closer Brad Hand back in Cleveland for an MRI on his left arm, Indians manager Terry Francona used three pitchers to get through the ninth inning. Nick Wittgren, Oliver Perez and Adam Cimber each got one out. Cimber struck out Albert Pujols with a runner on first for his first major-league save.

The Indians wanted Hand checked because his velocity had been decreasing the past couple outings. Francona said the MRI was clean.

The Angels again played without star outfielder Mike Trout.

Santana opened the scoring when he homered in the first off Dillon Peters (3-3). Lindor homered for the second consecutive night and for the fifth time this month.

Behind 4-0, the Angels rallied. Shohei Ohtani snapped a 0-for-11 skid in the fifth when he lined Adam Plutko's slider over the wall in right center for his 18th homer of the season. Kole Calhoun hit a solo homer in the eighth off Tyler Clippard.

Plutko started for the Indians and yielded two runs on six hits in 4 1/3 innings. The right-hander struck out three and walked two.

Trainer's room

Indians: Third baseman Jose Ramirez (right wrist) is still trying to grip the bat properly before resuming baseball activities.

Angels: Outfielder Justin Upton had an MRI after complaining of right knee discomfort and was held out of the lineup. He is 2-for-14 in the past four games. ... Pithcer Cam Bedrosian is being shut down for the rest of the season due to a right forearm strain.

Up next

Indians: Are off Thursday before right-hander Aaron Civale (3-3, 1.93 ERA) is the scheduled starter in Friday's opener against the Twins.